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doi: 10.1038/nrn.2017.68 3 TackJVerbeureWMoriHScholJVan Den HouteKHuangIet al
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Common early complaints can include: Nausea or a mildly unsettled stomach Feeling full after smaller meals Reduced interest in food Bloating or belching Indigestion or heartburn Diarrhea Constipation Abdominal discomfort Fatigue These symptoms overlap with adverse reactions listed in current prescribing information for Wegovy and Zepbound
Recent hypotheses suggest that GIP induces appetite suppression through independent receptors in the brain, mitigates gastrointestinal side effects of GLP-1 action, and prevents desensitization of GLP-1 receptors, thereby acting as a biased GLP-1RA [87]
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